Meiotic Chromosome Dynamics in C. elegans

Meiosis is an essential cell division process that creates haploid cells (e.g., sperm and eggs) from diploid precursors. Errors in meiosis cause many human reproductive problems, from infertility to birth defects. Using the nematode Caenorhabditis elegans as a model system for its excellent genetic and cytological qualities, we aim to find the mechanisms underlying correct pairing and synapsis of homologous chromosomes, as well as regulation of recombination.