How is genetic information maintained and passed on?

 

 
 
5-hydroxymethylcytosine (green) colocalizing with DNA damage made by laser irradiation (red)

5-hydroxymethylcytosine (green) colocalizing with DNA damage made by laser irradiation (red)

TET enzyme-mediated accumulation of 5hmC near sites of DNA damage

Many types of damage to DNA cause the local conversion of methylcytosine into hydroxymethylcytosine by the TET enzymes. This unexpected chemical modification of DNA in response to damage probably plays some role in repair, since deletion of the TET enzymes makes cells more sensitive to DNA damaging agents.

 

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